Designing Anti-Influenza Vaccines in Line
with the Populations Genetic Profile

Paper by RAS Academician G. G. Onishchenko^a and RAS Academician O. I. Kiselev^b†*

^aThe Russian Government, Moscow, Russia

^bResearch Institute of Influenza, St. Petersburg, Russia

e-mail: taruntaeva_na@aprt.gov.ru

Received January 20, 2016

Abstract—The changeability of viruses largely depends on adaptation to the conditions of reproduction and
mechanisms of the antiviral protection of host cells. Within populations, adaptation is associated with HLA spe-
cifics of identifying viral antigens. A population’s genetic profile and the diversity of HLA haplotypes affect
not only the morbidity rate but also the destiny of entire ethnic groups, their size, and premature mortality indi-
cators. Therefore, the solution to the problem of protecting a population against mass viral infections is impos-
sible without taking into account the HLA interethnic polymorphism, which specifies sensitivity to infections
and response to mass vaccination. Recent achievements in human genetics allow the system of preventive med-
icine to upgrade to the level of genetic personalization. In a multinational country like Russia, this approach
should become the basis for the preventive trend in practical medicine.

Keywords: anti-influenza vaccines, genetic profile of a population, high-risk groups, “excess mortality,” dissem-
ination paths of the main virus strains, genes, mutations, polymorphism.

DOI: 10.1134/S1019331616030199

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