The Pharmacological Strategy of Regenerative Medicine

Paper by RAS Academician A. M. Dygai*

Gol’dberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia

e-mail: dygai_am@pharmso.ru

Received December 22, 2015

Abstract—A rational approach to addressing the problems of regenerative medicine is pharmacological con-
trol over the functioning of endogenous stem cells by imitating natural regulatory systems of their functioning
in the organism. The analysis of data obtained on various models of pathological processes showed that the acti-
vation of bone marrow stem cells, observable in the majority of cases, turned out to be insufficient to compen-
sate for the existing damage. Despite the fact that granulocyte colony-stimulating factor and some other phar-
macological agents are characterized by an independent specific activity relative to progenitor cells of various
classes, the most significant therapeutic effects reached by activating cell turnover can be achieved under their
concomitant use with immobilized hyaluronidase.

Keywords: regeneration, stem cells, regulation, tissue microenvironment, cytokines, cirrhosis, lung fibrosis,
hyaluronidase, granulocyte colony-stimulating factor, immobilization, polyethylene glycol, intracellular sig-
naling molecules.

DOI: 10.1134/S1019331616030151

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