Recombinant Antibodies and Recombinant Proteins:
Prolonged-Action Drugs

Paper by RAS Corresponding Member A. G. Gabibov*

Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

e-mail: gabibov@gmail.com

Received January 18, 2016

Abstract—An intensively developing trend in modern biotechnology is the production of recombinant antibod-
ies and proteins. Recombinant antibodies have immunogenic properties and can stay in the blood for a long
time; neutralize pathogens, toxins, and viruses; and destroy tumor cells. Recombinant proteins are widely used
to cure, prevent, and diagnose diseases. A topical trend in modern medical biotechnology is the creation of pro-
longed-action drugs based on proteins obtained by genetic engineering methods. The issue of improving the
specificity and selectivity of preparations based on enzymes and antibodies awaits solution. Allthis can be
implemented using the approaches of modern combinatorial chemistry and biology, as well as quantum-
mechanical calculations.

Keywords: recombinant antibodies, recombinant proteins, immunobiotechnology, genetic engineering, Escher-
ichia coli, CHO cell line, combinatorial chemistry and biology, antidotes, quantum-mechanical calculations of
active centers of biocatalysts.

DOI: 10.1134/S1019331616030114

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