Vector Nanosystems for Drug Delivery to Target Cells

Paper by RAS Academician V. P. Chekhonin^a, RAS Academician A. A. Potapov^b,
and RAS Academician A. N. Konovalov^b *

^a Serbskii State Scientific Center for Social and Forensic Psychiatry of the Ministry of Health of the Russian Federation,
Moscow, Russia

^b Burdenko Research Institute of Neurosurgery, Moscow, Russia

e-mail: chekhoninnew@yandex.ru, apotapov@nsi.ru, akonovalov@nsi.ru

Received January 11, 2016

Abstract—Traditional approaches to chemotherapy remain ineffective in the case of aggressive tumors of the
central nervous system. In this context, new strategies of the targeted delivery of antitumor preparations are
actively being studied. This work presents the research results for vector nanocontainer systems based on anti-
Cx43 and anti-GFAP monoclonal antibodies for the therapy of experimental C6 glioma. The focus has been on
the creation of a C6 glioma model in rats, the synthesis of vector immunoliposome preparations, and the study
of the binding of C6 glioma cells with monoclonal anti-Cx43 and anti-GFAP antibodies in vivo after intrave-
nous infusion. Studies using the immunofluorescence method and intravital MRI have demonstrated the possi-
bility to visualize the periglioma space with the obtained nanocontainer systems, which makes it possible to
employ such systems for the targeted delivery of diagnostic and therapeutic agents to the periglioma zone of
high-grade gliomas.

Keywords: immunoliposomes, nanocontainers, monoclonal antibodies, targeted transport, Cx43, GFAP, glio-
blastoma, experimental C6 glioma.

DOI: 10.1134/S1019331616030102

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