Innovative Drugs: From Basic Research to Production

Paper by RAS Academician N. F. Myasoedov*

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

e-mail: nfm@img.ras.ru

Received January 22, 2016

Abstract—The results of studies of the molecular action mechanism of the peptides Semax and Selank—sim-
ple glyprolines that are used to prepare peptide-based drugs—are presented. A concept of creating an amino
acid sequence of peptides is given; their interaction with receptor systems of the cell and their influence on the
cell’s transcriptome, which forms the cell-mediated response, are considered. On the basis of the findings, phar-
maceutical compositions of peptide drugs have been developed and their production and introduction into clin-
ical practice have been organized.

Keywords: peptides, medical preparations, ligands, receptors, transcriptome, proteome, Semax, Selank, glypro-
lines.

DOI: 10.1134/S1019331616030084

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