Methodology of the Search for and Creation of Original Drugs

Paper by RAS Academician S. B. Seredenin*

Zakusov Research Institute of Pharmacology, Russian Academy of Sciences, Moscow, Russia

e-mail: seredeninpharm@mail.ru

Received December 7, 2015

Abstract—Original drugs are those that differ in the structure, mechanism, and formulation and that have
proved advantages over the existing preparations. The main goal of creating original drugs is to improve the
efficacy of pharmacotherapy. The author describes drug exploratory research and development methods: the
principle of similarity to physiologically active substances, the design of structures that affect selected targets
(receptors, ion channels, enzymes, chaperones, expression factors, etc.), and the study of the dependence of
pharmacological effects on the chemical structure, as well as the content of three stages of original drug devel-
opment, drawing specific examples of creating new drugs.

Keywords: drugs; pharmacological targets; exploratory, preclinical, clinical studies.

DOI: 10.1134/S1019331616030072

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