Russian Journal of General Chemistry. Vol. 92, No. 9, Pages 1806-1813, 2022

S. M. Mohammed^a, A. H. Moustafa^a, H. A. El-Sayed^a, A. S. Amin^b, A. Haggar^a, E. S. Tantawy^a, and R. A. Haggam^c^,*^,**

^aDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519 Egypt

^bDepartment of Chemistry, Faculty of Science, Benha University, Benha, 13518 Egypt

^cDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351 Saudi Arabia

Abstract— A highly efficient synthetic methodology for the preparation of 2-thioxocytosine was achieved by the nucleophilic addition of thiourea to α-cyanocinnamonitrile followed by intramolecular cyclization. The reaction smoothly proceeds in the presence of K₂CO₃-NPs as mild basic catalyst with yield 85%. The product was annulated to new imidazo[1,2-c]pyrimidine derivatives. Besides, Schiff base and acylated pyrimidine derivatives were synthesized via condensation or acylation with triethyl orthoformate, formic acid, maleic anhydride, benzoyl chloride or acetic anhydride.

Keywords: 2-thioxocytosine, 2-thioxopyrimidine, nano-K₂CO₃ catalyst, antimicrobial activity

A New Approach for Synthesis of 2-Thioxocytosine-5-carbonitrile as Antimicrobial Agents