Synthesis of New Fused Derivatives of 4-(Fur-2-yl)pyrano[4,3-b]pyridines

V. V. Dabaeva^a^,*, M. R. Baghdasaryan^a, I. M. Barkhudaryants^a, E. G. Paronikyan^a, H. A. Panosyan^a, and Sh. Sh. Dashyan^a

^aScientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

email: *valya.dabayeva@mail.ru

Received 7 June, 2022

Abstract— A method for the synthesis of new fused derivatives of 4-(fur-2-yl)pyrano[4,3-b]pyridines was developed by hydrolysis of 2-chloro-4-(2-furyl)-7,7-dimethyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile, its further reaction with hydrazine hydrate and thioglycolic acid. The direction of electrophilic substitution in the pyridine ring was studied.

Keywords: thiophene, furan, pyrano[4,3-b]pyridine, thieno[3,2-d]pyrimidine, electrophilic substitution

DOI: 10.1134/S1070363222090109