Russian Journal of General Chemistry. Vol. 92, No. 9, Pages 1610-1620, 2022

V. O. Topuzyan^a, A. A. Hovhannisyan^a, S. R. Tosunyan^a^,*, R. A. Tamazyan^a, A. G. Ayvazyan^a, and A. T. Makichyan^{a, b}

^aScientific Technological Center of Organic and Pharmaceutical Chemistry of National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Abstract— A method for the synthesis of 1-dialkylaminoalkyl-2-phenyl-4-arylidene-5-imidazolones from N-benzoyl-α,β-dehydroamino acid dialkylaminoalkylamides using trimethylchlorosilane and hexamethyldisilazane as dehydrating agents was proposed. The synthesized imidazolones were converted into the corresponding ammonium salts by reacting with various alkyl halides and acids. The anticholinesterase properties of 1-dialkylaminoalkyl-2-phenyl-4-arylidene-5-imidazolones and their quaternary ammonium salts were studied. It was found that the studied substances have anticholinesterase activity and are mainly specific for BuChE.

Keywords: 5-imidazolone derivatives, anticholinesterase properties, acetylcholinesterase, butyrylcholinesterase, N-benzoyl-α,β-dehydroamino acids amides, heterocyclization

Synthesis and Anticholinesterase Activity of 4-Arylidene-1-[ω-(dialkylamino)alkyl]-2-phenyl-4,5-dihydro-1(H)-imidazole-5-ones