Reactions of Ethyl 3-(4-Oxo-4H-chromen-3-yl)prop-2-enoates with 1,2-Binucleophiles

R. P. Kustin^a, N. M. Chernov^a^,*, R. V. Shutov^a, and I. P. Yakovlev^a

^aSt. Petersburg State Chemical Pharmaceutical University, St. Petersburg, 197376 Russia

email: *nikita.chernov@pharminnotech.com

Received 16 June, 2022

Abstract— Reactions of ethyl 3-(4-oxo-4H-chromen-3-yl)prop-2-enoates with 1,2-binucleophilic agents (hydrazine, phenylhydrazine, hydroxylamine) leads to the formation of some new pyrazole and isoxazole derivatives. The reactions proceed under mild conditions (ethanol, room temperature) to form the title products with high yields (71–99%).

Keywords: 4H-chromen-4-one, hydrazine, hydroxylamine, pyrazole, isoxazole, ANRORC reaction

DOI: 10.1134/S1070363222090031