Reaction of 5-Aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with Nucleophilic Agents

V. L. Gein^a^,*, D. D. Rubtsova^a, A. A. Gagarina^a, L. F. Gein^b, and M. V. Dmitriev^c

^aPerm State Pharmaceutical Academy, Perm, 614990 Russia

^bE. A. Vagner Perm State Medical University, Perm, 614990 Russia

^cPerm State National Research University, Perm, 614068 Russia

email: *geinvl48@mail.ru

Received 20 April, 2022

Abstract— The reaction of 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with p-toluidine proceeds at the carbonyl group in the side chain at the C⁴ atom of the heterocycle to form 5-aryl-4-[2-hetaryl(4-methylphenylamino)methylidene]-1-hydroxyethylpyrrolidine-2,3-diones. The reaction of 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones with hydrazine hydrate affords dihydro- and tetrahydropyrrolo[3,4-c]pyrazoles.

Keywords: 5-aryl-4-hetaroyl-3-hydroxy-1-hydroxyethyl-1,5-dihydro-2H-pyrrol-2-ones, p-toluidine, hydrazine hydrate

DOI: 10.1134/S1070363222090018