Biotesting in an Environmental Monitoring System: Safety Assessment of Rosin Derivatives

Abstract— According to the PASS prediction, resin acids and rosin derivatives can exhibit protective activity with respect to mucous membranes (P_a 71‒98%). Therefore, these substances can form the basis for drug development, which includes biotesting as a necessary step in biosafety assessment of drug candidates. Study of antibacterial activity by the disk diffusion method showed that the most toxic effect on E. coli and B. subtilis cells is characteristic of gum rosin, maleopimaric acid, and abietinol. Gum rosin exhibits fungicidal activity against C. tropicalis yeast. 12-Sulfodehydroabietic acid and its potassium salt affect the intensity of seed germination of Raphanus sativus L., and their toxicity is directly related to concentration. Complete inhibition of seed germination is observed at a concentration of 25 mg/mL.