Synthesis, Structure, and Properties of 2-Oxo-3-formylquinolone Acylhydrazone Containing a Trimethylammonium Fragment and also of Transition Metal Complexes Based on This Compound

L. D. Popova, * (https://orcid.org/0000-0001-9565-8005), Yu. P. Tupolovaa, V. G. Vlasenkoc (https://orcid.org/0000-0001-5470-1564), S. A. Borodkina (https://orcid.org/0000-0001-9550-1569), S. I. Levchenkova, b, V. E. Lebedeva, O. I. Askalepovaa, G. S. Borodkind (https://orcid.org/0000-0002-5886-7825), A. A. Zubenkoe (https://orcid.org/0000-0001-7943-7667), K. B. Gishkoa, Ya. V. Zubavichusf (https://orcid.org/0000-0003-2266-8944), V. A. Lazarenkog (https://orcid.org/0000-0002-3613-9763), and I. N. Shcherbakova (https://orcid.org/0000-0001-7799-5075)

aSouthern Federal University, Rostov-on-Don, 344090 Russia

bSouthern Scientific Center of the Russian Academy of Sciences, Rostov-on-Don, 344006 Russia

cScientific Research Institute of Physics, Southern Federal University, Rostov-on-Don, 344090 Russia

dInstitute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, 344090 Russia

eNorth-Caucasian Zonal Research Veterinary Institute, Novocherkassk, 346406 Russia

fG.K. Boreskov Institute of Catalysis SB RAS, Synchrotron Radiation Facility SKIF, Koltsovo, Novosibirsk region, 630559 Russia

gNational Research Center “Kurchatov Institute”, Moscow, 123182 Russia

email: *ldpopov@mail.ru

Received 29 July, 2022

Abstract— The product of 3-formyl-2-quinolone condensation with trimethylammonium chloride acethydrazide, (H2L+)Сl– hydrazone, was synthesized. Complexes of Zn(II) and Cu(II), [M(HL)OCH3]ClO4, with a distorted square-planar strucrure of coordination sites and asymmetric chelate сomplexes of Mn(II), Ni(II), and Co(II), [M(HL)(H2L)]·(ClO4)3, of pseudo-octahedral structure were obtained on its basis. The protistocidal, antibacterial, and fungistatic activities of the synthesized compounds were studied.

Keywords: hydrazones, metal complexes, X-ray absorption spectroscopy, X-ray diffraction analysis, biological activity

DOI: 10.1134/S1070363222120301