Synthesis, Antibacterial, and Antifungal Screening of New Pyrazolo[3,4-d]pyrimidine Derivatives

G. G. Dubal^a^,* (https://orcid.org/0000-0002-0055-5407), P. R. Vachchharajani^c, M. J. Solanki^b (https://orcid.org/0000-0002-2616-8106), and V. H. Shah^c

^aDepartment of Chemistry, School of Science, RK University, Rajkot, 360020 India

^bC. U. Shah Science College, Ahmedabad, 380014 India

^cDepartment of Chemistry, Saurashtra University, Rajkot, 360005 India

email: *dr.gaurangdubal@gmail.com

Received 12 July, 2022

Abstract— A series of 3-amino-4-substituted phenyl-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-d]pyrimidin-6-imines was synthesized. In vitro antibacterial and antifungal screening indicated that some compounds show good inhibition in comparison with standard drugs amoxycillin, chloramphenicol, ciprofloxacin, norfloxacin, griseofulvin, and nystatin.

Keywords: pyrimidine, pyrazolo[3,4-d]pyrimidine, antibacterial activity, antifungal activity, antimicrobial activity

DOI: 10.1134/S1070363222120234