Chiral Salts of Dithiophosphonic Acids on the Basis of Monoterpenyl Alcohols and Cinchona Alkaloids

I. S. Nizamov^a^,* (http://orcid.org/0000-0002-2058-773X), A. A. Yakovlev^a (http://orcid.org/0000-0001-5313-2494), O. V. Shilnikova^a (http://orcid.org/0000-0003-4548-4566), Ye. N. Nikitin^b, I. D. Nizamov^a (http://orcid.org/0000-0002-8243-3533), E. S. Batyeva^b (http://orcid.org/0000-0002-3142-0679), and R. A. Cherkasov^a

^aKazan (Volga Region) Federal University, Kazan, 420008 Russia

^bArbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088 Russia

email: *isnizamov@mail.ru

Received 3 October, 2022

Abstract— Reactions of O-terpenyl dithiophosphonic acids with cinchona alkaloids lead to the formation of quinuclidinium salts of these acids. Quinuclidinium salts possess antimicrobial activity against Bacillus cereus, Staphylococcus aureus and Candida albicans.

Keywords: dithiophosphonic acids, cinchona alkaloids, chirality, antimicrobial activity

DOI: 10.1134/S1070363222120106