First-Generation Dendrimers Based on Thiacalix[4]arene Containing Hydroxyl Terminal Groups: Synthesis and Self-Assembly

I. E. Shiabiev^a, D. A. Pysin^a, P. L. Padnya^a, and I. I. Stoikov^{a, b}^,*

^aA.M. Butlerov Chemistry Institute of Kazan (Volga Region) Federal University, Kazan, 420008 Russia

^bFederal Center for Toxicological, Radiation, and Biological Safety, Kazan, 420075 Russia

email: *ivan.stoikov@mail.ru

Received 30 September, 2022

Abstract— irst-generation dendrimers containing thiacalix[4]arene in cone and 1,3-alternate conformations as a core and hydroxyl groups as terminal moieties have been synthesized. It has been shown that self-assembly of the dendrimers with the macrocyclic core in cone conformation and terminal amidoethanol groups in an aqueous solution leads to the formation of stable monodisperse supramolecular system consisting of the nanoparticles with hydrodynamic diameter of 11.4±0.1 nm.

Keywords: thiacalix[4]arene, macrocycle, dendrimers, self-assembly, nanoparticles

DOI: 10.1134/S1070363222120040