Russian Journal of General Chemistry. Vol. 92, No. 11, Pages 2516-2520, 2022

A. U. Isakhanyan^a^,*, N. Z. Hakobyan^a, A. S. Grigoryan^a, K. G. Navoyan^a, G. V. Gasparyan^a, R. P. Mkhitaryan^a, G. A. Panosyan^a, and A. A. Harutyunyan^a

^aScientific and Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Abstract— Acylation of 2-amino-5,5-dimethyl-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carbonitrile and 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile with various acids chlorides in anhydrous dioxane furnished the corresponding amides. Coordination compounds were obtained by reacting copper(II) chloride, zinc(II), cobalt(II), and barium(II) acetates with N-(5,5-dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide. Anti-MAO activity of the synthesized compounds was studied.

Keywords: amides, acylation, complexes, coordination compounds, ligand, anti-MAO activity

Synthesis and Anti-MAO Activity of Acylation Products of Annelated Thiophene-2-amine and N-(5,5-Dimethyl-3-cyano-4,7-dihydro-5H-thieno[2,3-c]pyran-2-yl)-4-chlorobutanamide and Their Complexes with Cu(II), Zn(II), Ba(II), and Co(II)