Synthesis of Novel 2-{[6-(3,5-Dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]thio}acetohydrazide Derivatives and Their Biological Properties

T. A. Gomktsyan^a, R. S. Shainova^a, A. V. Karapetyan^a, E. A. Ghazaryan^a, S. V. Harutyunyan^a, A. S. Vorskanyan^a, A. P. Yengoyan^{a, b}^,*, and V. A. Pivazyan^a

^aResearch Center for the Pesticides Synthesis and Expertise, National Agrarian University of Armenia, Yerevan, 0009 Armenia

^bDepartment of General and Pharmaceutical Chemistry, Russian-Armenian University, Yerevan, 0051 Armenia

email: *ayengoyan@mail.ru

Received 20 July, 2022

Abstract— Pyrazolylpyridazine is an interesting non-fused biheterocyclic system, which derivatives have a wide spectrum of biological activity. In this study, a targeted synthesis of a number of new potentially biologically active derivatives based on the corresponding 2-{[6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazin-3-yl]thio}acetohydrazide was carried out. The synthesized compounds showed a pronounced stimulating effect on plant growth.

Keywords: pyrazolylpyridazin-3-ylthioacetohydrazide, 1,2,4-triazole-3-thiol, plant growth stimulants, 1,3,4-thiadiazole(oxadiazole)-2-thione, arylideneacetohydrazides, E,Z-isomerism

DOI: 10.1134/S1070363222110354