Synthesis, Antibacterial, and Antioxidant Activity of N-Acyl Derivatives of Annelated 2-Aminothiophene

A. U. Isakhanyan^a^,*, N. Z. Akopyan^a, G. M. Stepanyan^a, A. G. Arakelyan^a, Zh. M. Buniatyan^a, R. E. Muradyan^a, G. A. Panosyan^a, and A. A. Harutyunyan^a

^aScientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

email: *anush.isakhanyan.51@mail.ru

Received 4 July, 2022

Abstract— Acylation of 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile and 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbonitrile with various acids chlorides afforded the corresponding amides. Boiling ethyl 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate with certain acids chlorides leads to formation of the corresponding amides. The antibacterial and antioxidant activity of synthesized compounds was studied.

Keywords: amides, 2-amino-3-cyano(ethoxycarbonyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophenes, acylation, antioxidant, antibacterial activity

DOI: 10.1134/S1070363222110317