Russian Journal of General Chemistry. Vol. 92, No. 11, Pages 2379-2389, 2022

Yuxuan Xia^a, Jiaxin Ma^a, Jiayao Zheng^a, Ziyi Lu^a, Qiong Zhang^a, Baowei Li^a, Siyu Chen^a, Dongmei Li^a, Qiang Zhang^b, Liu Hong^a^,*, Bingtian Zhao^a^,**, and Cheng Yang^a

^aKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122 China

^bSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, 215009 China

Abstract— Fullerene (C₆₀) has been regarded as an effective radical scavenger for many years, but the highly hydrophobic nature strongly limits its application in biological fields. Herein, a simple and green strategy for synthesizing water-soluble fullerene derivative was reported, in which intrinsic C₆₀ was grafted by amine oxide functional group (AO-C₆₀). In addition to its excellent aqueous dispersion, AO-C₆₀ exhibited extremely low toxicity to mice macrophage cell RAW264.7. Further experiments have confirmed the prominent antioxidative ability of AO-C₆₀ towards typical free radicals including 1,1-diphenyl-2-picrylhydrazy (DPPH) radical, hydroxyl radical (^•OH) and nitric oxide (^•NO) without the help of metal loading, while the IC₅₀ could be as low as 0.09 mg/mL. Our work will shed light on the development of anti-oxidative nanoagents with both effectiveness and bio-safety.

Facile Synthesis of Biocompatible Amine Oxide Grafted Fullerene and Its Antioxidant Performances without Metal Loading