Reactions of Tetramethyl Ethynyldiphosphonate with Substituted 2-Aminopyridines

K. N. Dakuo^a, A. S. Krylov^a, and N. I. Svintsitskaya^a^,*

^aSt. Petersburg State Institute of Technology (Technical University), St. Petersburg, 190013 Russia

email: *nsvincickaya@mail.ru

Received 14 July, 2022

Abstract— The base-catalyzed hydroamination reaction of teramethyl ethynyldiphosphonate with substituted 2-aminopyridines was studied. The reaction proceeds stereoselectively with the formation of (E)-enaminophosphonates. A series of new phosphonoenamines, namely dimethyl [2-(dimethoxyphosphoryl)-2-(pyridin-2-ylamino)vinyl]phosphonates, was obtained.

Keywords: enamines, enaminophosphonates, alkinylphosphonates, aminopyridines, vicinal bisphosphonates

DOI: 10.1134/S107036322211010X