Synthesis and Analgesic Activity of Etyl 4-[(4-Aryl-2-hydroxy-4-oxobut-2-enoyl)amino]benzoates

V. L. Gein^a^,*, A. V. Romanova^a, O. V. Bobrovskaya^a, O. V. Nazarets^a, R. R. Makhmudov^b, and Е. V. Gradova^b

^aPerm State Pharmaceutical Academy, Perm, 614990 Russia

^bPerm State Natsional Research University, Perm, 614990 Russia

email: *geinvl48@mail.ru

Received 13 June, 2022

Abstract— The reaction of methyl esters of 4-aryl-2-hydroxy-4-oxobut-2-enoic acids (aroylpyruvic acids) with 4-aminobenzoic acid ethyl ester (benzocaine, anesthesin) in glacial acetic acid in the presence of anhydrous sodium acetate gave rise to ethyl (Z)-4-(4-aryl-2-hydroxy-4-oxobut-2-enamido)benzoates. Analgesic activity of the synthesized compounds was studied.

Keywords: ethyl (Z)-4-(4-aryl-2-hydroxy-4-oxobut-2-enamido)benzoates, 4-aminobenzoic acid ethyl ester (benzocaine, anesthesin), analgesic activity

DOI: 10.1134/S1070363222110056