Reactions of Isonicotinic Acid Hydrazide and Its Trimethylsilyl Derivatives with Isocyanates

L. O. Belova^a, N. A. Golub^a^,*, M. V. Pletneva^a, N. I. Kirilina^b, and A. D. Kirilin^a

^aMIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technology), Moscow, 119571 Russia

^bState Research Institute of Chemistry and Technology of Organoelement Compounds, Moscow, 105118 Russia

email: *golub-n.a@mail.ru

Received 9 July, 2022

Abstract— Reactions of isonicotinic acid hydrazide and its trimethylsilyl derivatives with hexamethyldisilazane, organic, and organosilicon isocyanates were studied. The possibility of synthesizing previously unknown isoniazid derivatives by preliminary introduction of a trimethylsilyl substituent to the nitrogen atom was established.

Keywords: isonicotinic acid hydrazide, N-(trimethylsilyl)isonicotinohydrazide, trimethylsilyl isocyanate, (trimethoxysilylpropyl)isocyanate, hexamethyldisilazane, semicarbazides

DOI: 10.1134/S1070363222110032