Design, Synthesis, SAR, Pharmacokinetic Prediction of New 4-Quinolones as Anti-Microbial Agents

G. G. Dubal^a^,*, P. R. Vachchharajani^b, M. J. Solanki^c, and V. H. Shah^b

^aDepartment of Chemistry, School of Science, RK University, Rajkot, 360020 India

^bDepartment of Chemistry, Saurashtra University, Rajkot, 360005 India

^cC. U. Shah Science College, Ahmedabad, 380014 India

email: *dr.gaurangdubal@gmail.com

Received 23 August, 2022

Abstract— s of new 4-quinolone derivatives was synthesized by conventional heating method. For the synthesized compounds, we performed pharmacokinetic prediction, SAR and antimicrobial assay. The presence of halogen elements plays a key role in the biological activity that is clear by in vitro analysis. Target compounds exhibit moderate to significant activity near to standard marketed drugs like amoxycillin, chloramphenicol, ciprofloxacin, norfloxacin, griseofulvin, and nystatin.

Keywords: lone, anti-microbial activity, SAR, pharmacokinetic prediction, Swiss ADME, drug likeness

DOI: 10.1134/S1070363222100280