Biscarbazole Derivatives: Synthesis, Characterization, Antimicrobial and Antitumor Activity, and Molecular Docking Study
F. Çelika, A. Aydınb, K. İ. Bektaşc, H. İ. Gülerc, A. Nalçaoğluc, and Y. Ünvera, *
aDepartment of Chemistry, Faculty of Sciences, Karadeniz Technical University, Trabzon, 61080 Turkey
bDepartment of Basic Medical Science, Faculty of Medicine, Bozok University, Yozgat, 66100 Turkey
cDepartment of Molecular Biology and Genetics, Karadeniz Technical University Faculty of Science, Trabzon, 61080 Turkey
email: *unver.yasemincan@hotmail.com
Received 24 June, 2022
Abstract—
New series of biscarbazole derivatives containing imine-amine groups was synthesized. Antimicrobial activity of newly synthesized compounds against bacterial strains and yeast isolates was determined. The effects of the synthesized test compounds on cell proliferation and NCI-60 survival parameter values were measured. In addition, in silico analysis against five different receptors with synthesized two compounds was carried out to see the necessary interactions responsible for anti-bacterial activity. The docking results of both compounds supported the antibacterial activity exhibiting high inhibition constants.
Keywords:
carbazole,
amine,
imine,
antimicrobial activity,
antitumor activity,
docking study
DOI: 10.1134/S1070363222100279