Facile Synthesis, Antioxidant and Antimicrobial Activities of Diethyl((4-isopropylphenyl)(substituted phenylamino)methyl)phosphonates

Abstract— The one-pot, three component and facile synthesis of diethyl ((4-isopropylphenyl) (substitutedphenylamino)methyl)phosphonate 4a–4j has been achieved from the reaction of 4-isopropylbenzaldehyde 1 with various substituted amines 2a–2j and diethyl phosphite 3 using Kabachnik–Fields reaction under room temperature and solvent free conditions using nano Cu₂O as a stable, noncorrosive, low-cost, recyclable, eco-friendly heterogeneous catalyst. Furthermore, melting point, IR, NMR, and mass spectra were used to interpret this new series of compounds. The newly synthesized formulations were evaluated in vitro for antioxidant and antimicrobial activity, and they executed well when compared to the standard.