Russian Journal of General Chemistry. Vol. 92, No. 10, Pages 2092-2107, 2022

M. Akki^a, D. S. Reddy^b, K. S. Katagi^a^,*, A. Kumar^b, V. Babagond^a, R. S. Munnolli^c, and S. D. Joshi^d

^aDepartment of Chemistry, Karnatak University’s Karnatak Science College, Dharwad, 580001 India

^bCentre for Nano and Material Sciences, Jain University, Bangalore, 562112 India

^cDepartment of Chemistry, KLS Vishwanathrao Deshpande Institute of Technology, Haliyal, 590018 India

^dNovel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, S.E.T.’s College of Pharmacy, SR Nagar, Dharwad, 580002 India

Abstract— A series of novel benzyl 5-(substitutedphenyl)-3-(2-oxo-2H-chromen-3-yl)-4,5-dihydro-1H-pyrazole-1-carbodithioate were obtained. The anti-cancer activity of synthesised compounds against lung cancer (A-549) and breast cancer cell lines (MDA-MB-231) was investigated by MTT assay. The most of the synthesised compounds were effective against both cancer cell lines and demonstrated significant cytotoxicity. Molecular docking investigation of the synthesised compounds and the cyclin dependent kinase-2 (CDK2) protein revealed that the synthesised compounds displayed greater C-score values, validating the findings.

Coumarin-Pyrazole Linked Carbodithioates as Potential Anti-Сancer Agents: Design, Synthesis, Biological, and Molecular Docking Investigation