Russian Journal of General Chemistry. Vol. 92, No. 10, Pages 2082-2091, 2022

Srinivas Endoori^a, Venkateswara Rao Anna^a^,*, Kali Charan Gulipalli^a, Srinu Bodige^a, Anil Kumar Pommidi^a, Sri Ramakrishna Surapureddi^a, and Nareshvarma Seelam^a^,**

^aDepartment of Engineering Chemistry, College of Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, 522302 India

Abstract— A novel series of imidazo[1,2-a] pyridine linked 1,2,3-triazole derivatives has been designed, synthesized and the structures have been confirmed by ¹H and ¹³C NMR and mass spectral analysis. The synthesized compounds have been evaluated for their in vitro cytotoxic activity against two cancer cell lines along with normal cell line (HEK293) by MTT assay. Among all the tested compounds, the derivative with 3-methoxyphenyl moiety exhibits potent inhibitory activity against MCF-7 and Hela cell lines with IC₅₀ values of 2.55 and 3.89 µM respectively.

Keywords: synthesis, imidazo[1,2-a] pyridine linked 1,2,3 triazole derivatives, anticancer, molecular docking, PI3K_α enzyme

Synthesis, Characterization, and Anticancer Activity of Novel Imidazo[1,2-a]pyridine Linked 1,2,3-Triazole Derivatives