Synthesis of Phosphoramidates Based on Aminopyridines

A. S. Krylov^a^,*, Yu. L. Piterskaya^a, V. V. Gurzhiy^b, D. Yu. Voronina^a, and A. V. Dogadina^a

^aSt. Petersburg State Institute of Technology (Technical University), St. Petersburg, 190013 Russia

^bSt. Petersburg State University, St. Petersburg, 199034 Russia

email: *alexandr_krylov@bk.ru

Received 24 June, 2022

Abstract— Reaction of diethyl chlorophosphate with aminopyridines furnished a series of new diethyl phosphoramidates. The effect on the reactivity of substituents in the pyridine ring was studied. Structure of the obtained compound was characterized by ¹H, ¹³C, ³¹P, 2D HMBC ¹H–¹⁵N NMR spectroscopy, mass-spectrometry, and single crystal X-ray diffraction analysis.

Keywords: diethyl chlorophosphate, phosphoramidates, aminopyridines, phosphorylation

DOI: 10.1134/S1070363222100061