Synthesis and Structure of Methyl 6-Aryl-5-aroyl-4-hydroxy2-oxo(thioxo)hexahydropyrimidine-4-carboxylates

V. L. Gein^a^,*, T. M. Zamaraeva^a, E. V. Gorgopina^a, and M.V. Dmitriev^b

^aPerm State Pharmaceutical Academy, Perm, 614990 Russia

^bPerm State National Research University, Perm, 614990 Russia

email: *geinvl48@mail.ru

Received 16 June, 2022

Abstract— The reaction of aroylpyruvic acids methyl esters with aromatic aldehyde and urea (thiourea) in methanol leads to the formation of methyl 6-aryl-5-aroyl-4-hydroxy-2-oxo(thioxo)hexahydropyrimidine-4-carboxylates. Structure of the obtained compounds was established by ¹H, ¹³C NMR spectroscopy and single crystal X-ray diffraction analysis.

Keywords: Biginelli reaction, aroylpyruvic acids methyl esters, arylaldehydes, urea, thiourea, 4-hydroxy-2oxo(thioxo)pyrimidine

DOI: 10.1134/S1070363222100036