The Electrochemical Properties of Dopamine,
Epinephrine and their Simultaneous Determination
at a Poly(L-methionine) Modified Electrode¹

W. Ma^z and D. M. Sun^z

Department of Chemistry, Huaibei Coal Normal College,
100 Dongshan Road, Huaibei Anhui Province 235000 P.R. China

Abstract—A poly(L-methionine) modified electrode, fabricated by electrochemical immobilization of the L-
methionine on a glassy carbon electrode, was used for simultaneous determination of dopamine and epineph-
rine through cyclic voltammetry. The electrochemical properties of dopamine and epinephrine have been inves-
tigated. This sensor gave two separated cathodic peaks at –0.282 and 0.112 V for EP and DA, respectively. A
linear response was obtained in the range of 5.0 10⁷ to 1.0 10⁴ mol l^–1 for epinephrine, and 1.0 10⁶ to
5.0 10⁴ mol l^–1 for dopamine. The detection limits were 3.6 10⁷ mol l^–1 and 4.2 10⁷ mol l^–1 for epineph-
rine and dopamine, respectively. This method was successfully applied for simultaneous determination of
dopamine and epinephrine in human urines.

Key words: L-methionine, Dopamine, Epinephrine, Simultaneous determination, Modified electrode

DOI: 10.1134/S1023193507120087

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