Voltammetric Determination of Ciprofloxacin Based
on the Enhancement Effect of Cetyltrimethylammonium
Bromide (CTAB) at Carbon Paste Electrode¹

Hongchao Yi^a,b and Chunya Li^b,z

^a College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, 430074 China

^b College of Chemistry and Environmental Engineering, Yangtze University Jingzhou, 434023 China

Abstract—Herein, an electrochemical method was developed for the determination of ciprofloxacin based on
the enhancement effect of cetyltrimethylammonium bromide (CTAB). In pH 7.0 phosphate buffer, a poorly-
defined oxidation peak is observed at carbon paste electrode (CPE) for ciprofloxacin. However, the oxidation
peak current remarkably increases in the presence of low concentration of CTAB, suggesting that CTAB exhib-
its obvious enhancement effect to the determination of ciprofloxacin. All the experimental parameters, such as
supporting electrolyte, pH value, concentration of CTAB, and accumulation time, were optimized for ciprof-
loxacin analysis. This new method possesses high sensitivity (detection limit is 5.0 10⁸ mol l^–1), wide linear-
ity (1.0 10⁷2.0 10⁵ mol l^–1), rapid response, low cost and simplicity. Finally, this method was successfully
employed to detect ciprofloxacin in drugs.

Key words: ciprofloxacin, determination, surfactant effect, carbon paste electrode, drug analysis

DOI: 10.1134/S1023193507120075

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