paste electrode (CPE) by using the cyclic voltammetry technique in aqueous solution containing o-toluidine
(OT), sulfuric acid and SDS. Then, copper oxide was incorporated by immersion of POT(SDS)/CPE in a solu-
tion of copper sulfate and using constant potential method. Then, the electrochemical characterization of the
modified electrode is presented in alkaline solution. For the first time, electrochemical behaviour of amoxicillin
(AMX) at the Cu/POT(SDS)/CPE has been investigated using cyclic voltammetry (CV) and chronoamperomet-
ric method. The experimental results suggest that the modified electrode exhibits electrocatalytic effect on the
oxidation of AMX resulting in a marked enhancement of the anodic peak current response. Under the selected
conditions, the anodic peak current was linearly dependent on the concentration of AMX in the range 80–200
and 5–150
M with CV and amperometric method, respectively. The detection limits (2
) were also estimated to be 60 and 3
M. Some kinetic parameters such as the transfer second-order rate constant (k = 4.9 
106 cm3 mol–1 s–1) of AMX was calculated. Therefore, this modified electrode was a simple, rapid and new electrode to
determine AMX in pharmaceutical preparations.