E. B. Grigorkina, N. M. Lyubashevsky, and G. V. Olenev
Institute of Plant and Animal Ecology, Ural Division, Russian Academy of Sciences, ul. Vos’mogo Marta 202,
Yekaterinburg, 620144 Russia
Received February 6, 1998
Abstract—Studies on 600 animals (inbred and outbred laboratory mice and bank voles from a natural popula-
tion) revealed differences in their response to equal (by LD50/30) gamma-radiation doses received against a
background of drug-induced stress: the period of mortality significantly decreased in inbred mice, did not differ
from the control in outbred mice, and increased in voles. At the same time, preliminary exposure to stress did
not lead to significant changes in the proportion of animals that died from irradiation. The data obtained are
interpreted as evidence of the leading role of the genotype in radioresistance and of the validity of the corre-
sponding approach to the assessment of heterogeneity of laboratory colonies and natural populations of rodents.
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