Effect of Illumination Regime
on Life Span in Drosophila melanogaster

A. A. Moskalev and O. A. Malysheva

Institute of Biology, Komi Scientific Center, Ural Division, Russian Academy of Sciences,

ul. Kommunisticheskaya 28, Syktyvkar, 167982 Komi Republic, Russia;

e-mail: amoskalev@ib.komisc.ru

Received November 30, 2007

Abstract—Accelerated aging of Drosophila strains with impaired detoxification of free radicals (Sod) and
DNA repair (mus-210) under illumination as compared to the wild type has been demonstrated. In contrast, in
a strain carrying a defective homolog of mammalian gene PCNA, the life span increases under conditions of
round-the-clock illumination compared to constant darkness. The first review of the possible mechanisms
underlying the effect of the illumination regime on the life span is presented, with special emphasis on the roles
of the disturbance of normal circadian rhythms, increase in fecundity and physical activity (metabolic rate), and
the neuroendocrine control of the insulin/IGF-1 pathway.

DOI: 10.1134/S1067413609030102

Key words: life span, illumination regime, circadian rhythms, fecundity.

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