Role of Apoptosis in Age-Related Pathologies

V. G. Zainullin¹ and A. A. Moskalev²

¹Institute of Biology, Komi Research Center, Ural Division, Russian Academy of Sciences,
Syktyvkar, 167000 Komi Republic, Russia

²Syktyvkar State University, Syktyvkar, 167982 Russia

Received July 5, 1999; in final form, March 6, 2000

Abstract—A review of recent data concerning the apoptotic death of cells during senescence at the organismic
level. The data analyzed suggest interrelations between apoptosis deregulation and some age-related patholo-
gies and senescent phenotypes. Genetic aspects and possible mechanisms of age-related changes in the program
of apoptosis are considered. It has been proposed that age-related deregulation of apoptosis is a mechanism of
senescence.

Key words: senescence, apoptosis, life span, age-related pathologies

Pleiades Publishing home page | journal home page | top

If you have any problems with this server, contact webmaster.