Synthesis and Antiviral Activity of Copolymers of Hydroxycinnamic Acid with N-Vinylamides
N. A. Nesterovaa,*, A. A. Shtrob, and Corresponding Member of the RAS E. F. Panarina
a Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, 199004 Russia
b Smorodintsev Research Institute of Influenza,
Russian Ministry of Health, St. Petersburg, 197376 Russia
Correspondence to: *e-mail: lab.2305@mail.ru
Received 8 June, 2023
Abstract—Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) has been used to prepare copolymers of various composition with variable molecular weights. Subsequent reactions in their polymer chains affords water-soluble copolymers of salts of hydroxycinnamic acid and its hydrazides. The synthesized copolymers of hydroxycinnamic acid salts and hydrazides with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).
Keywords: coumarin, copolymers of hydroxycinnamic acid, N-vinylamides, antiviral activity, hydroxycinnamic acid hydrazides
DOI: 10.1134/S0012500823600992