Study of the Antitumor Activity in Vitro of Iodo-δ-Lactones of 5Z,9Z-Dienoic Acid
E. Kh. Makarovaa,*, I. V. Ishbulatova, A. A. Makarova, L. U. Dzhemilevab,
Corresponding Member of the RAS U. M. Dzhemilevb, and V. A. D’yakonovb
a Institute of Petrochemistry and Catalysis,
Ufa Federal Research Center, Russian Academy of Sciences, Ufa, 450075 Russia
b Zelinsky Institute of Organic Chemistry,
Russian Academy of Sciences, Moscow, 119991 Russia
Correspondence to: *e-mail: makarovaelina87@gmail.com
Received 23 May, 2023
Abstract—Previously unknown phenyl-substituted iodo-δ-lactone derived from 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized in 94% yield using the Ti-catalyzed intermolecular cross-cyclomagnesiation of aromatic 1,2-diene with O‑containing allene at the key stage. The in vitro cytotoxic activity of synthesized alkyl- and phenyl-substituted iodo-δ-lactones of 5Z,9Z-dienoic acids against the Jurkat, K562, U937, HL60, and Hek293 cell lines was studied, and their effect on the cell cycle and the ability to induce apoptosis were investigated using flow cytometry.
Keywords: cross-cyclomagnesiation, 1,2-dienes, iodo-δ-lactones, Cp2TiCl2, cytotoxic activity, apoptosis, Jurkat, K562, U937, HL60, HEK293
DOI: 10.1134/S0012500823700209