Yu. M. Chumakova, V. I. Tsapkovb, E. Jeanneauc,
N. N. Bairacb, G. Bocellid, D. Poiriere, J. Roye, and A. P. Guleab
a Institute of Applied Physics, Academy of Sciences of Moldova, Academiei 5, Chisinau, 2028 Moldova
e-mail: chumakov.xray@phys.asm.md
b State University of Moldova, ul. Matteevicha 60, Chisinau, 2009 Moldova
c Laboratoire des Multimatériaux et Interfaces, Université Claude Bernard, Lyon, France
d Institute of Materials for Electronics and Magnetism, National Research Council (IMEM–CNR), Parma, Italy
e Centre Hospitalier Universitaire de Québec (CHUQ), Sainte-Foy (Quebec), Canada
Received October 17, 2007
Abstract—The crystal structures of chloro-(2-formylpyridinethiosemicarbazono)copper dimethyl sulfoxide
solvate (I), bromo-(2-formylpyridinethiosemicarbazono)copper (II), and (2-formylpyridinethiosemicarba-
zono)copper(II) nitrate dimethyl sulfoxide solvate (III) are determined using X-ray diffraction. In the crystals,
complexes I and II form centrosymmetric dimers in which the thiosemicarbazone sulfur atom serves as a bridge
and occupies the fifth coordination site of the copper atom of the neighboring complex related to the initial com-
plex through the center of symmetry. In both cases, the coordination polyhedron of the complexing ion is a dis-
torted tetragonal bipyramid. Complex III in the crystal structure forms polymer chains in which the copper
atom of one complex forms the coordination bond with the thiocarbamide nitrogen atom of the neighboring
complex. In this structure, the coordination polyhedron of the central atom is an elongated tetragonal bipyra-
mid. It is established that complexes I–III at a concentration of 10–5 mol/l selectively inhibit the growth of 60
to 90percent of the cancer tumor cells of the human myeloid leukemia (HL-60).
PACS numbers: 61.66.Dk, 87.14.-g
DOI: 10.1134/S1063774508050106
Pleiades Publishing home page | journal home page | top
If you have any problems with this server, contact webmaster.