G. V. Gurskaya*, V. E. Zavodnik**, and A. D. Shutalev***
* Éngelhardt Institute of Molecular Biology, Russian Academy of Sciences,
ul. Vavilova 32, Moscow, 119991 Russia
e-mail: gurskaya@eimb.ru
** Karpov Research Institute of Physical Chemistry, State Scientific Center,
ul. Vorontsovo pole 10, Moscow, 103064 Russia
*** Lomonosov State Academy of Fine Chemical Technology,
pr. Vernadskogo 86, Moscow, 117571 Russia
Received March 15, 2002
Abstract—The structures of three 5-acetyl-1,2,3,4-tetrahydropyrimidin-2-ones(thiones), namely, 5-acetyl-4-
ethyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2-thione, 5-acetyl-6-methyl-4-(4-methylphenyl)-1,2,3,4-tetrahy-
dropyrimidine-2-thione, and 5-acetyl-4-(4-methoxyphenyl)-6-methyl-1,2,3,4-tetrahydropyrimidin-2-one,
which are potential medicinals, are studied by X-ray diffraction. The conformational features of the molecules
studied are analyzed. For these compounds, the dependence of the conformation of the tetrahydropyrimidine
ring on the orientation of the substituent at the C(4) atom with respect to the heterocycle is found. © 2003 MAIK
“Nauka/Interperiodica”.
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