Effects of Hydrolysable Tannins on Native
and Artificial Biological Membranes

M. P. Borisova^a, A. A. Kataev^b, S. M. Mavlyanov^c, and N. G. Abdullajanova^c

^aInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences,

ul. Institutskaja, 3, Pushchino, Moscow oblast, 142290 Russia

e-mail: mdborisova@bk.ru

^bInstitute of Cell Biophysics, Russian Academy of Sciences,
ul. Institutskaja, 3, Pushchino, Moscow oblast, 142290 Russia

^cInstitute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan,

ul. Kh. Abdullaeva, 83, Tashkent, 100125 Uzbekistan

Received January 17, 2014

Abstract—Effects of hydrolysable tannins on plasma membranes of Chara corallina giant cells and lipid
bilayer membrane (BLM) were studied. Tannin inhibited chloride channels of alga cell membranes in a dose-
dependent manner. Current jumps emerging in BLM in the presence of tannin suggest formation of ion chan-
nels, predominantly anion selective. The presence of cholesterol in BLM increased the open state lifetime of
the channels. The findings indicate that hydrolysable tannins possess a membrane activity and are capable to
form anion channels in a cell membrane.

Keywords: tannin, ion channels, Chara corallina, BLM

DOI: 10.1134/S1990747814040023

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