Gajanand Sharmaa, 2, Richa Sharmab, Meenakshi Sharmac, Anshu Dandiad, and Preeti Bansala
a Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur
b Department of Biotechnology and Food Science, Jayoti Vidyapeeth Women’s University, Jaipur
c Department of Botany, University of Rajasthan, Jaipur
d Anshu Dandia, Centre of Advanced Studies, Department of Chemistry, University of Rajasthan
Received May 14, 2012; in final form, November 12, 2012
Abstract—An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-
DHPs) incorporating 2-oxindole/piperidines is performed in 5–8 min with reasonable purity in 80–90% yield
under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to
be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-
dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermato-
phytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment
of dermatophytosis or ringworm infections.
Keywords: montmorillonite KSF, microwave irradiation, MCRs, spiro-1,4-DHPs
DOI: 10.1134/S106816201303014X
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