Eco-Friendly Synthesis and in vitro Antibacterial Activities
of Some Novel Chalcones¹

Salman A Khan^{a, 2}, Abdullah M. Asiri^{a, b}, Khalid A. Alamry^a,
Samy A. El-Daly^a, and Mohie A. M. Zayed^a

^a Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

^b Center of Excellence for Advanced Materials Research, King Abdulaziz University,
P.O. Box 80203, Jeddah 21589, Saudi Arabia

Received September 18, 2012; in final form December 7, 2012

Abstract—Chalcone derivatives have been synthesized by reaction of 1-(2,5-dimethyl-furan-3-yl)-ethanone
with corresponding active aldehyde in ethanolic NaOH in microwave oven. The structure of these compounds
was established by elemental analysis, IR, ¹H NMR, ¹³C NMR, and EI-MS spectral analysis. The anti-bacterial
activity of these compounds was first tested in vitro by the disc diffusion assay against two Gram-positive and
two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the
reference of standard drug chloramphenicol. The results showed that pyrazol containing chalcone (compound
8) inhibited both types of bacteria (Gram-positive and Gram-negative) better than chloramphenicol.

Keywords: chalcones, anti-bacterial activity, chloramphenicol

DOI: 10.1134/S1068162013030072

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