Pyranocoumarins from Zosima absinthifolia (Vent) Link Roots¹

Seyed Mehdi Razavi^{a, 2}, Gholamhasan Imanzadeh^b, Fatemeh Soghra Jahed^b, and Gholamreza
Zarrini^c

^a Department of Biology, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

^b Department of Chemisrty, Faculty of Sciences, University of Mohaghegh Ardabili, Ardabil, Iran

^c Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Received April 2, 2012; in final form, June 22, 2012

Abstract—Zosima absinthifolia (Vent) Link (Apiaceae) is a perennial herb indigenous to Iran. It has been used
as a medicinal plant from ancient time in Iran, Turkey and Pakistan. In the present work, air-dried and powdered
plant roots were extracted with n-hexane, dichloromethane and methanol, respectively, using Soxhlet apparatus.
The dichloromethane extract was subjected to vacuum liquid chromatography (VLC) and prepara-tive thin layer
chromatography (P-TLC) to yield two pyranocoumarins, aegelinol and agasyllin. The antimicrobial assay was
performed using agar dilution method. The results showed that purified compounds have modest to weak anti-
bacterial and antifungal activity.

Keywords: Zosima absinthifolia, aegelinol, agasyllin, pyranocoumarin

DOI: 10.1134/S106816201301010X

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