Synthesis and Biological Evaluation of Novel
Isoxazolo[4,3-e]indoles as Antibacterial Agents¹

Mehdi Pordel², Amin Abdollahi, and Bahareh Razavi

Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Received July 30, 2012; in final form, August 6, 2012

Abstract—The synthesis of a new series of 8-bromo-6-alkyl-1-aryl-6H-isoxazolo[4,3-e]indole derivatives is
described. All the newly synthesized compounds were screened for their antibacterial activity against Escheri-
chia coli HB101, Staphylococcus aureus pathogens (methicillin resistant S. aureus and methicillin susceptible
S. aureus), Pseudomonas aeruginosa, and Bacillus subtilis; also MIC values of these compounds were deter-
mined.

Keywords: isoxazolo[4,3-e]indole, antibacterial agents, Staphylococcus aureus, MIC

DOI: 10.1134/S1068162013020106

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