In Vitro Anticarcinogenic, Antiparasitic and Antimicrobial Effects of P. granatum Extract

Abstract—In this study, antimicrobial, anticarcinogenic and antiparasitic effects of pomegranate (Punica granatum L.) peel were investigated. Peels were separated from pomegranate fruit obtained in season from local markets and markets in Istanbul, Beykoz, and phenolic components were determined by extracting them at 33% ethanol, 78°C and 5 hours operating conditions. It was determined that punigagalagin, caffeic acid, epicatechin and Catechin were the highest in phenolic contents. The obtained extract showed antimicrobial effect against selected microorganisms. In addition, the in vitro anticarcinogenic activity of the extract was determined in breast cancer, gastric cancer and lung cancer cell lines. Finally, the antiparasitic activity of pomegranate peel extract was determined in L. major and L. infantum parasites promostigots and amostigotes, which are cutaneous and visceral leishmaniasis agents. It has been concluded that pomegranate peel extract will be used not only in the food industry but also in non-food applications due to its medicinal properties.