Synthesis and Properties of Functionally Substituted Phthalocyanines: From Photocatalysis to Photodynamic Therapy

E. A. Gorbunovaa, N. E. Kononenkoa, Ya. N. Korovkinaa, T. V. Dubininaa, *, and E. R. Milaevaa

aDepartment of Chemistry, Moscow State University, Moscow, 119991 Russia

email: *dubinina.t.vid@gmail.com

Received 21 June, 2024

Abstract— This review focuses on the main methods for obtaining functionally substituted phthalocyanine complexes, as well as the precursor phthalonitriles containing various hydrophilic and hydrophobic groups. It presents a comparison of the optical and photochemical properties of phthalocyanines, including pathways for generating reactive oxygen species. The potential applications of phthalocyanines are outlined, including photocatalysis, fluorescent diagnostics, and photodynamic therapy for cancer and antibacterial treatments.

Keywords: phthalocyanines, medicinal chemistry, photodynamic therapy, reactive oxygen metabolites, spectroscopy, fluorophores

DOI: 10.3103/S0027131424700421