Application of Matrix Solid-Phase Dispersion Combined with Gas Chromatography-Mass Spectrometry for the Determination of Bisphenol A in Fresh-Water Fishes

Abstract— Matrix solid-phase dispersion using a humate-based magnetic sorbent is proposed as an efficient method for the concentration of bisphenol A from fish muscular and hepatic tissue samples followed by the chromatography-mass spectrometry determination of an analyte prederivatized with acetic anhydride. Under the optimum concentration conditions (the stirring time is 10 min and the sorbent weight is 0.05 g), the recovery of bisphenol A upon single sorption reaches 85%. The percentage desorption exceeds 99% (the eluate is methanol, the time is 3 min, and the volume is 1 mL). The maximum enrichment factor is 718. The limit of the detection of bisphenol A is 0.15 μg/kg (on a dry basis) for muscular tissue and 0.25 μg/kg for liver.