Non-Destructive Analysis of Tetracycline Drugs by the Digital Colormetric Method Using a Smartphone and the Photometrix Pro® Software

Abstract— A nondestructive analysis of tetracyclines in drugs by their own fluorescence using a smartphone and a device printed on a 3D printer is proposed. The possibility of using chemometric methods, which reduce the analysis time and visualize the obtained data, is shown. The dataset is processed by principal component analysis (PCA), hierarchical cluster analysis (HCA), partial least squares (PLS) regression, and least squares using the PhotoMetrix PRO^® software. The use of chemometric methods of analysis to determine the concentration of the active substance and identify the manufacturer of medicinal products is considered.