Cryochemical Synthesis of Hybrid Nanoforms Based on Silver and Antibacterial Drug Dioxidine by the Low-Temperature Condensation of Vapor from the Gas Phase

Abstract— Hybrid nanoforms based on silver and the antibacterial drug dioxidine (2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-N-oxide) are prepared by the method of joint cocondensation of metal and ligand vapors on a liquid nitrogen-cooled surface. The samples obtained are characterized by FTIR-, UV-Vis, and XPS-spectroscopy, as well as ТЕМ, SEM, and powder X-ray phase analysis (ХРА). It is shown that cryomodified nanoforms preferably consist of the anhydrous triclinic (T-phase) crystal phase of dioxidine. The dimensions of dioxidine particles ranged from 50 to 300 nm and the average size of doping silver nanoparticles is 15 ± 3 nm. The broadening of the diffraction patterns belonging to silver shows the transition of metallic silver to the nanoscale state. The FTIR results indicate hybrid nanoforms stabilized by the donor-acceptor interactions of surface silver atoms with the hydroxyl groups and with the donor N-atoms of quinoxaline cycles of dioxidine molecules.